Search Results - kenneth+maclean

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Polyamines for the Treatment of Homocystinuria

Dr. MacLean and Dr. Jiang have found that spermine and spermidine are novel therapeutics for the treatment of Homocystinuria. In-vivo studies have demonstrated low spermine and spermidine levels in mouse models with HCU phenotype. The inventors believe that spermine and spermidine supplementation may provide clinical benefit in patients with HCU. Download...

Published: 10/23/2023 | Inventor(s): Kenneth MacLean, Hua Jiang

Disease Areas

Category(s): Therapeutics

Cystathionine for Treatment of Liver and Kidney Injury, Cardiovascular Protection & Chemotherapy Potentiation

Researchers have discovered that cystathionine reduces the development of toxin-induced liver and/or kidney disease and is also capable of blocking tunicamycin-mediated tissue injury and apoptosis. Findings suggest that cystathionine may be a new treatment option in many disease states where cell death is triggered by stress to the endoplasmic reticulum...

Published: 5/22/2023 | Inventor(s): Kenneth MacLean, Richard Austin

Disease Areas Hematology, Regenerative Medicine

Category(s): Therapeutics

Improved Treatment for Homocystinuria

A research group led by Dr. Kenneth MacLean at the University of Colorado has shown that a combination of formate treatment with betaine could dramatically improve clinical outcome in Homocystinuria (HCU), a rare metabolic condition characterized by an excess of homocysteine in the urine. This new treatment removes the need for a methionine restricted...

Published: 3/24/2023 | Inventor(s): Kenneth MacLean, Johan Van Hove, Hua Jiang

Disease Areas

Category(s): Therapeutics