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Protective Role of MUC5B in Airflow Obstruction

In the lungs, the two major airway mucins secreted into airspaces are MUC5AC and MUC5B. In human asthma, both mucins are expressed at similar levels. In mice, Muc5ac is required for the development of asthma-like airflow obstruction. In this discovery, the Evans lab reports that Muc5b is protective in a mouse asthma model. This is the first time showing...

Published: 5/30/2023 | Inventor(s): Christopher Evans

Disease Areas Pulmonology

Category(s): Therapeutics