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Oxindol-3-ylidene inhibitors of AMP-activated protein kinase (AMPK)
The oral tyrosine kinase inhibitor sunitinib, used in the clinic to treat advanced renal cell carcinoma and gastrointestinal stromal tumors, is a potent AMPK inhibitor. However, sunitinib has been associated with clinical cardiac toxicity through non-specific binding to the AMPKα2 isoform. Dr. Philip Reigan and a team of researchers have revealed...
Published: 11/30/2023
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Inventor(s):
Philip Reigan
,
Donald Backos
,
Christopher Matheson
,
Craig Jordan
Disease Areas
Oncology
Category(s):
Therapeutics
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