Search Results - craig+jordan

1 Results

Sort By:

Oxindol-3-ylidene inhibitors of AMP-activated protein kinase (AMPK)

The oral tyrosine kinase inhibitor sunitinib, used in the clinic to treat advanced renal cell carcinoma and gastrointestinal stromal tumors, is a potent AMPK inhibitor. However, sunitinib has been associated with clinical cardiac toxicity through non-specific binding to the AMPKα2 isoform. Dr. Philip Reigan and a team of researchers have revealed...

Published: 11/30/2023 | Inventor(s): Philip Reigan, Donald Backos, Christopher Matheson, Craig Jordan

Disease Areas Oncology

Category(s): Therapeutics