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Transgenic mice that overexpress Muc5b in the lungs

CU researchers have created a transgenic mouse model that overexpresses a major gel-forming mucin, Muc5b, in the lungs. To drive tissue-specific expression, the coding region of Muc5b is under control of the rat secretoglobin 1a1 (Scgb1a1) promoter. Evidence from human patient samples combined with this mouse model have been used demonstrate that excess...

Published: 5/22/2023 | Inventor(s): David Schwartz

Disease Areas Pulmonology

Category(s): Research Tools