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Transgenic mouse model of pulmonary hypertension

The inventors have developed a system of transgenic mice in which the mutation found in human families, loss of the type II BMP receptor, is recreated in an inducible and tissue specific manner, to be used as an in vivo model with high molecular fidelity. The dominant negative transgene consists of a promoter, gene, and polyadenylation sequence. The...

Published: 5/22/2023 | Inventor(s): James West, David Rodman

Disease Areas Pulmonology

Category(s): Research Tools