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Drugs That Reverse Epithelial-Mesenchymal Transition For The Treatment Of Metastatic Cancers
Epithelial-mesenchymal transition (EMT) is a driving force in tumor progression that transforms relatively benign epithelial tumor cells into mesenchymal or quasi-mesenchymal cells with cancer stem cell (CSC) properties, promoting the malignant phenotype that is highly drug resistant and metastatic. University of Colorado researchers have discovered...
Published: 11/30/2023
|
Inventor(s):
Daniel LaBarbera
,
Qiong Zhou
,
Adedoyin Abraham
Disease Areas
Oncology
Category(s):
Therapeutics
Novel anti-metastatic agents that reverse epithelial-mesenchymal transition (EMT) in cancer (CHD1L).
Colorectal cancer (CRC) is one of the most prevalent forms of cancer with over 150,000 new cases reported each year. Stage 4 CRC patients have very poor survival rates at only 11% and there are currently no effective therapeutics for treating metastatic CRC. The epithelial-mesenchymal transition (EMT) is a driving force for tumor progression, tumor...
Published: 12/1/2023
|
Inventor(s):
Daniel LaBarbera
,
Qiong Zhou
,
Joshua Abbott
,
Hector Esquer
,
Brett Prigaro
Disease Areas
Oncology
Category(s):
Therapeutics
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