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Immune targeting for the treatment of Cutaneous T-Cell Lymphoma

Cutaneous T-Cell Lymphoma (CTCL) has risen dramatically and consistently since 1973 with approximately 1,600 new cases of CTCL diagnosed each year in the US. Currently, there is no cure for CTCL and it is characterized by a chronic, relapsing course that requires repeat treatment regimens. The survival and response rate to CTCL therapeutics are only...

Published: 7/6/2023 | Inventor(s): Zhirui Wang, Christene Huang, David Mathes, Elizabeth Pomfret

Disease Areas Dermatology, Immunology, Oncology

Category(s): Therapeutics

Bivalent EGF- Diphtheria Fusion Toxin For The Treatment Of Head And Neck Cancer

Head and neck cancers (HNC) are the 9th most common malignancy and 6th most deadly worldwide. 80% of HNCs are squamous cell carcinomas (HNSCC). The overall response and survival rate for HNSCC are quite low, and there is a dramatic need for effective and targeted treatments of HNSCC. EGF Receptor (EGFR) is highly expressed in over 90% of HNSCCs, making...

Published: 8/29/2022 | Inventor(s): Zhirui Wang, Shi-Long Lu

Disease Areas Oncology

Category(s): Therapeutics