Two Layer Retinal Tissue Transplant for


A University of Colorado research group led by Dr. Maria Valeria Canto-Soler has developed a new technique to produce a dual layer retinal tissue transplant derived from human induced pluripotent stem cells (hiPSC) containing a layer of photoreceptor cells and an underlying layer of retina pigmented epithelial (RPE) cells.  Together, the photoreceptor and RPE layers recreate the cellular organization and functional processes of the human retina.  This dual-layer implant is the first to use technology that generates stem cell-derived human retinal tissue with functional light-sensitive photoreceptors. The new technology also allows the generation of highly mature functional RPE tissue that shows the characteristic pigmented cobblestone pattern, is polarized and expresses functional proteins of mature RPE tissue, achieves physiological trans-epithelial resistance and shows polarized release of bioactive molecules.


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For Information, Contact:
Mary Tapolsky
University of Colorado
Maria Canto-Soler
Miguel Flores-Bellver
Disease Areas:
Regenerative Medicine
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