Novel Compounds Targeting RNA Polymerase Binding Transcription Factor DksA for Treatment of Drug-Resistant Gram-Negative Infections


Scientists at the University of Colorado and National Jewish Health have identified novel compounds that specifically inhibit DksA activity in Gram-negative bacteria. Drugs against DksA have antibiotic activity against several Gram-negative pathogens. Moreover, the newly discovered drugs act against persistent populations of intracellular bacteria and potentiate antimicrobial activity of other antibiotics.


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For Information, Contact:
Mary Tapolsky
University of Colorado
Michael Wempe
Andres Vazquez-Torres
Shaodong Dai
Disease Areas:
Infectious Disease
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