Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) Mimetic


Dr. Huntington Potter at the University of Colorado Anschutz Medical Center has shown that GM-CSF (recombinant human Granulocyte-Macrophage Colony-Stimulating Factor such as the commercially available Leukine) can slow or reverse Alzheimer’s disease (AD) (CU#4306H).  However, continuous treatment of AD patients with Leukine would be expensive at its current cost (>$200,000/year/patient) and it would be difficult to produce sufficient quantities. To counter these difficulties, Dr. Potter has developed new GM-CSF peptides that act as GM-CSF mimetics.  The mimetics are smaller in size and easier to synthesize than GM-CSF itself. They also show improved bioavailability, improved stability, easier administration, improved blood brain barrier permeability, and improved oral bioavailability.


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For Information, Contact:
Aoife Cullen
University of Colorado
Huntington Potter
Glenn Simon
Disease Areas:
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