A Method to High Efficiency Concersion of Fibroblasts into Beating Cardiomyocytes for Heart Muscle Regeneration


Dr. Song at the University of Colorado has developed a new technology that allows heart muscle regeneration by converting fibroblasts into cardiomyocytes in situ via gene therapy. Using the new method, about 60% of fibroblasts express cardiac Troponin T (cTnT) and about 50% express α-actinin. Beating cardiomyocytes are observed in less than 2 weeks. Dr. Song also effectively converted fibroblasts into cardiomyocytes in an intact beating rodent heart using an adeno-associated virus-based gene delivery method.   


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For Information, Contact:
Doreen Molk
University of Colorado
Kunhua Song
Yuanbiao Zhao
Pilar Londono
Timothy McKinsey
Disease Areas:
Regenerative Medicine
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