Neuroprotective effects of metalloporphyrins against chemical threat agents


Oxidative stress as a therapeutic target for nerve agent toxicity. Researchers at the University of Colorado have defined oxidative stress as a mechanism of brain injury resulting from nerve agent and its surrogates. They have identified oxidative stress as an important therapeutic target for chemical agent-induced neurotoxicity and cognitive dysfunction using a lead metalloporhyrin, AEOL10150.

Key references:

•       Pearson-Smith JN, Liang LP, Rowley SD, Day BJ, Patel M. Oxidative Stress Contributes to Status Epilepticus Associated Mortality Neurochem Res. 2017 Jul;42(7):2024-2032. PMID: 28462450.

•       Pearson JN, Patel M. The role of oxidative stress in organophosphate and nerve agent toxicity, NYAS Special Issue: Countermeasures against chemical threats; New York Acad Sci. doi: 10.1111/nyas; 13115; 2016.

•       Liang LP, Pearson-Smith LN, Huang J., McElroy P, Day  BJ,Patel M. Neuroprotective Effects of AEOL 10150 in a Rat Organophosphate Model Toxicol. Sci. 162(2):611-621. 2018.

•       Liang LP, Pearson-Smith LN, Huang J., Day  BJ, Patel M. Neuroprotection of AEOL 10150 in a Rat Soman Model Redox biology; 20:275-284; 2019.

•       Pearson-Smith JN, Patel M. Antioxidant drug therapy as a neuroprotective countermeasure of nerve agent toxicity. Neurobiol Dis. Apr 25;. doi: 10.1016/j.nbd.2019.


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For Information, Contact:
Mary Tapolsky
University of Colorado
Manisha Patel
Li-Ping Liang
Simon Waldbaum
John McManus
Disease Areas:
Emergency Medicine
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