Monoclonal antibody against human NAD(P)H:quinone Oxidoreductase 1 (NQO1)


CU scientists have developed a monoclonal antibody against human NAD(P)H:quinone Oxidoreductase 1 (NQO1), which is an FAD-binding protein that plays a role in reduction reactions and has altered expression in many cancers. The anti-NQO1 antibody was raised in mouse and does not cross react with NQO2. Additionally, the antibody is reactive against human, monkey, dog, and rat NQO1. It has also been tested in several applications such as immunoblot analysis, immunohistochemistry, immunocytochemistry, and immunoprecipitation.


Siegel D, Franklin WA, Ross D. Immunohistochemical detection of NAD(P)H:quinone oxidoreductase in human lung and lung tumors. Clin Cancer Res. 1998;4(9):2065-2070.


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Aaron Troemner
University of Colorado
David Ross
David Siegel
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