Stable Formulations of Glucagon for Injection with Minimal Pain


Researchers at the University of Colorado have designed stable, concentrated, freeze-dried glucagon formulations that can be injected with minimal pain. These formulations are prepared by drying glucagon with a carbohydrate and buffer and can be reconstituted as a solution, suspension, or paste. These compositions have increased chemical and physical stability at ambient or elevated temperatures. They can be delivered to patients in a concentrated form, allowing for minimally painful administration using low-volume, shallow injection through a fine needle. Whereas stable glucagon formulations are being developed by other companies, they must be administered using large volumes, meaning they will still require painful injections.

For Information, Contact:
Mary Tapolsky
University of Colorado
John Carpenter
Wei-Jie Fang
John Kinzell
Steven Prestrelski
Disease Areas:
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