Generation of Human Motor Neurons


­Background on CU5150H
Human motor neuron diseases are irreversible and devastating diseases for which there are no curative treatments. Animal models lack the genotypic and phenotypic features seen in human motor neuron diseases, so human-derived motor neuron models are of high interest. However, current protocols for human models require long maturation times and generate heterogenous cell populations. This limits both experimental size and data accuracy. To date, the lack of rapid, scalable and functional in vitro human motor neuron model is a critical barrier in drug testing and development. This system enables fast and scalable production of functional motor neurons from human induced pluripotent stem cells that is necessary for large experiments, unbiased genetic screens, and cell replacement therapies.

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For Information, Contact:
Doreen Molk
University of Colorado
Holger Russ
Lori Sussel
Laura Hudish
Disease Areas:
Regenerative Medicine
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