Search Results - glenn+furuta

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Transgenic mice that overexpresses IL-5 and serve as a model of eosinophilic oesophagitis (EoE)

CU investigators have created a transgenic mouse model that overexpresses IL-5 in the oesophageal epithelium and serves as a mouse model for inflammatory changes associated with eosinophilic oesophagitis (EoE). Tissue-specific expression of IL-5 is achieved using the squamous epithelial promoter Epstein-Barr virus ED-L2. These mice have expanded eosinophilopoietic...

Published: 5/9/2023 | Inventor(s): Glenn Furuta, Joanne Masterson

Disease Areas

Category(s): Research Tools

A Novel Treatment for Eosinophilic Esophagitis

Eosinophilic esophagitis (EoE) is a rapidly emerging medical condition (affecting one in 2,000 people globally) caused by eosinophil infiltration into the esophagus and GI tract. Current treatments do not address the underlying cause of EoE; namely, esophageal immune cell infiltration. A University of Colorado research team has found that a monoclonal...

Published: 6/16/2023 | Inventor(s): Glenn Furuta, Joanne Masterson

Disease Areas Gastroenterology, Regenerative Medicine

Category(s): Therapeutics