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Transgenic mice that overexpresses IL-5 and serve as a model of eosinophilic oesophagitis (EoE)
CU investigators have created a transgenic mouse model that overexpresses IL-5 in the oesophageal epithelium and serves as a mouse model for inflammatory changes associated with eosinophilic oesophagitis (EoE). Tissue-specific expression of IL-5 is achieved using the squamous epithelial promoter Epstein-Barr virus ED-L2. These mice have expanded eosinophilopoietic...
Published: 5/9/2023
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Inventor(s):
Glenn Furuta
,
Joanne Masterson
Disease Areas
Category(s):
Research Tools
A Novel Treatment for Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is a rapidly emerging medical condition (affecting one in 2,000 people globally) caused by eosinophil infiltration into the esophagus and GI tract. Current treatments do not address the underlying cause of EoE; namely, esophageal immune cell infiltration. A University of Colorado research team has found that a monoclonal...
Published: 6/16/2023
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Inventor(s):
Glenn Furuta
,
Joanne Masterson
Disease Areas
Gastroenterology
,
Regenerative Medicine
Category(s):
Therapeutics
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