A Novel Treatment for Eosinophilic Esophagitis


Eosinophilic esophagitis (EoE) is a rapidly emerging medical condition (affecting one in 2,000 people globally) caused by eosinophil infiltration into the esophagus and GI tract. Current treatments do not address the underlying cause of EoE; namely, esophageal immune cell infiltration. A University of Colorado research team has found that a monoclonal antibody targeting granulocyte-macrophage colony-stimulating factor (GM-CSF) may be a potential treatment for EoE.  In a mouse model, the inventors reduced GM-CSF levels by administering a GM-CSF neutralizing monoclonal antibody and found that it diminished some negative consequences of EoE, such as eosinophil infiltration into the esophagus, basal cell hyperplasia, and angiogenesis.


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For Information, Contact:
Doreen Molk
University of Colorado
Glenn Furuta
Joanne Masterson
Disease Areas:
Regenerative Medicine
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