Search Results - jerome+schaack

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Adenovirus Transducible 3T3-L1 Cells to advance genetic study of obesity

Genetic manipulation, altering native DNA or introducing foreign/exogenous DNA into cells, has proven to be an invaluable research tool to identify and study proteins integral in basic cellular function and disease but 3T3-L1 cells do not naturally lend themselves to the transfer (transduction) of genetic material. A research team led by James DeGregori...

Published: 12/1/2023 | Inventor(s): David Orlicky, James DeGregori, Jerome Schaack

Disease Areas Endocrine/Metabolism, Regenerative Medicine

Category(s): Research Tools

Genetically-Engineered Cyclic Nucleotide-Gated Ion Channels as Sensors for Intracellular Cyclic AMP

Dr. Jeffrey Karpen and his research team have developed a novel research tool with a high signal-to-noise ratio for improved spatial and temporal resolution to be used in the detection of cyclic adenosine monophosphate (cAMP), a signaling molecule present in many cell types. To do this, researchers genetically engineered cyclic nucleotide-gated ion...

Published: 5/22/2023 | Inventor(s): Jeffrey Karpen, Thomas Rich, Dermot Cooper, Jerome Schaack, Kent Fagan

Disease Areas

Category(s): Research Tools