Search Results - kimberly+casalvieri

1 Results

Sort By:

Inhibitors of Wee1 kinase for pediatric and adult cancers

The Wee1 kinase participates in the G2-M checkpoint to prevent mitosis in the presence of DNA damage and therefore may play an important role in drug resistance to DNA alkylating agents, by allowing tumor cells to repair DNA damage prior to mitosis. Inhibition of the Wee1 kinase is known to potentiate the effect of chemotherapy in a variety of tumor...

Published: 11/30/2023 | Inventor(s): Philip Reigan, Donald Backos, Christopher Matheson, Kimberly Casalvieri

Disease Areas Oncology

Category(s): Therapeutics