Inhibitors of Wee1 kinase for pediatric and adult cancers


The Wee1 kinase participates in the G2-M checkpoint to prevent mitosis in the presence of DNA damage and therefore may play an important role in drug resistance to DNA alkylating agents, by allowing tumor cells to repair DNA damage prior to mitosis.  Inhibition of the Wee1 kinase is known to potentiate the effect of chemotherapy in a variety of tumor types.  CU researchers have created a library of potent inhibitors of the Wee1 kinase with a favorable cytotoxicity profile for pediatric and adult cancers.


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For Information, Contact:
Mary Tapolsky
University of Colorado
Philip Reigan
Donald Backos
Christopher Matheson
Kimberly Casalvieri
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