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Targeting Claudins to Enhance Apoptic Response of Cancer Cells

Dr. Margaret Neville and her research team have developed a novel peptide that targets and disrupts claudins, a family of tight junction proteins. Dr. Neville has shown that disruption of claudins initiates a cellular signaling cascade that activates the death receptor pathway causing apoptosis of epithelial cells. This disruption caused a seven-fold...

Published: 11/30/2023 | Inventor(s): Margaret Neville, Robert Hodges, Neal Beeman

Disease Areas Oncology

Category(s): Therapeutics