Search Results - robert+hodges

4 Results

Sort By:

Antimicrobial Peptides to Treat Gram-negative infections

The growing emergence of pathogenic bacteria with clinical significant resistance to conventional antibiotics is a major public health concern. There has been a revival of polymyxins which have serious issues of nephrotoxicity/ neurotoxicity as antibiotics of last resort. Resistance to polymyxins means that no antibiotics are available for the treatment...

Published: 5/7/2023 | Inventor(s): Robert Hodges, Colin Mant, Lajos Gera, Ziqing Jiang

Disease Areas

Category(s): Therapeutics

Novel Compounds Show Promise in Treating Variety of Cancers

A group of researchers led by Lajos Gera and Robert Hodges has developed two sets of compounds: flurbiprofen analogs and silylalkyloxyaryl amino acid analog compounds that have proven to be effective against a wide variety of cancer cell lines. Both were screened using the NCI-60 cell lines, a panel of 60 diverse human cancer cell lines used by National...

Published: 5/7/2023 | Inventor(s): Lajos Gera, Robert Hodges, Peter Hegyes, Daniel Muruve

Disease Areas Oncology

Category(s): Therapeutics

Targeting Claudins to Enhance Apoptic Response of Cancer Cells

Dr. Margaret Neville and her research team have developed a novel peptide that targets and disrupts claudins, a family of tight junction proteins. Dr. Neville has shown that disruption of claudins initiates a cellular signaling cascade that activates the death receptor pathway causing apoptosis of epithelial cells. This disruption caused a seven-fold...

Published: 11/30/2023 | Inventor(s): Margaret Neville, Robert Hodges, Neal Beeman

Disease Areas Oncology

Category(s): Therapeutics

Novel Compounds Show Promise in Treating Variety of Cancers

Published: 5/21/2023 | Inventor(s): Lajos Gera, Daniel Chuen-Fong Chan, Robert Hodges, Paul Bunn

Disease Areas Oncology

Category(s): Therapeutics