Generation of Engraftable Hematopoietic Stem Cells from Induced Pluripotent Stem Cells


A University of Colorado research group led by Dr. Michael Verneris has developed a novel process to create autologous hematopoietic stem cells (HSCs) that are engraftable in patient bone marrow.  Human iPS cells are treated with a small molecule (SM1). SM1 changes the gene expression in iPS-derived HSCs, giving them a genetic signature associated with bone marrow engraftment in mice and the associated ability to engraft in mice. In addition, treatment with SM1 resulted in more than two-fold expansion of HSCs over the course of 12 days of culture and led to increased iPSC-derived human HSC engraftment in immune-deficient mice.


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For Information, Contact:
Doreen Molk
University of Colorado
Michael Verneris
Seonhui Shim
Disease Areas:
Regenerative Medicine
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