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Homing of Chimeric Antigen Receptor Expressing T cells to Solid Tumors

One major challenge in targeting CAR T cells to patients with solid tumors is the limited homing of CAR T cells to solid tumors. The University of Colorado research group led by Dr Michael Verneris has developed a CAR construct to target CAR-T cells to IL-8 (CXCL8) producing target tumors. This chemokine is commonly expressed by tumors (brain, lung,...

Published: 10/27/2023 | Inventor(s): Michael Verneris, Jessica Lake

Disease Areas Oncology

Category(s): Therapeutics

Innate Lymphoid Cell (ILC) Therapy for GvHD

High refractory and mortality of GvHD Hematopoietic stem cell transplantation (HSCT) is curative for a variety of malignant and non-malignant disorders with no other therapeutic options. Graft versus host disease (GvHD) accounts for morbidity and mortality after HSCT. GVHD occurs in 30 to 60% of HSCT cases and carries approximately a 50% mortality rate....

Published: 10/23/2023 | Inventor(s): Michael Verneris, Dejene Tufa

Disease Areas Immunology, Oncology

Category(s): Therapeutics

Generation of Engraftable Hematopoietic Stem Cells from Induced Pluripotent Stem Cells

Engraftment Challenge in Bone Marrow Transplantation Bone marrow transplant is currently used to treat leukemia, lymphoma and genetic bone marrow failure disorders, but it can be highly risky especially when a closely matched donor is not available. Only one third of patients even have a viable donor for bone marrow transplantation. Generation of autologous...

Published: 10/23/2023 | Inventor(s): Michael Verneris, Seonhui Shim

Disease Areas Oncology, Regenerative Medicine

Category(s): Therapeutics