In order to overcome the issue of rapid circulatory clearance of some small molecule, protein, or antibody drugs, University of Colorado researchers have developed a novel method to piggyback drugs or proteins to the plasma membrane of red blood cells (RBCs). To do this, the research team synthesized derivatives of lipid-based dye and then subsequently conjugated a variety of cargo molecules. When incubated with RBCs, the lipid molecules decorate the RBC plasma membrane and the cargo molecules are exposed to the exterior. In one proof-of-concept study, mice infused with RBCs painted with lipid molecules carrying an antibody, cetuximab, had 5.5-fold higher blood cetuximab levels relative to cetuximab administered in its free form. Therefore, this approach has utility in preventing rapid circulatory clearance of potentially useful pharmacologic therapies for disease.
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