Search Results - dmitri+simberg

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Targeted Nanogels for Urinary Bladder Therapies

Drs. Devatha Nair and Dmitri Simberg at the University of Colorado developed a nanogel specifically designed to treat Urinary Tract Infections (UTIs). The nanogel allows a localized and sustainable delivery of drugs within the urothelium. The nanogel is formed as a polymeric 3-dimensional network which is biodegradable and naturally excreted by the...

Published: 11/30/2023 | Inventor(s): Devatha Nair, Dmitri Simberg, Manju Saraswathy

Disease Areas Nephrology, Oncology, Regenerative Medicine

Category(s): Therapeutics

Lipid Derivatives for Drug Delivery via Red Blood Cells

In order to overcome the issue of rapid circulatory clearance of some small molecule, protein, or antibody drugs, University of Colorado researchers have developed a novel method to piggyback drugs or proteins to the plasma membrane of red blood cells (RBCs). To do this, the research team synthesized derivatives of lipid-based dye and then subsequently...

Published: 6/14/2023 | Inventor(s): Dmitri Simberg, Weston Smith

Disease Areas Oncology

Category(s): Therapeutics

Lipid Derivatives For Drug Delivery

A team of researchers, led by CU’s Dr. Dmitri Simberg have created nano-formulated, fluorescent indocarbocyanine lipids (ICL) to improve delivery of therapeutic agents to tumor and tumor-associated immune cells. The concept has been tested and validated in vitro and in vivo where the novel compound outcompeted DOXIL, a standard chemotherapeutic,...

Published: 6/15/2023 | Inventor(s): Dmitri Simberg, Hanmant Gaikwad, Irina Balyasnikova

Disease Areas

Category(s): Therapeutics