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Urate Transport Inhibitors: Compounds Designed for Their Uricosuric Action

Heightened urate levels are prevalent in a variety of disease states, including gout, hypertension, diabetes, and cardiovascular disease. Currently, there are few drugs approved in the USA for the lowering of blood urate levels. Among those marketed, many either have extreme unintended maladies, like Stevens Johnson syndrome, require frequent dosing,...

Published: 5/25/2023 | Inventor(s): Michael Wempe, Hitoshi Endou

Disease Areas Nephrology

Category(s): Therapeutics

Targeted Nanogels for Urinary Bladder Therapies

Drs. Devatha Nair and Dmitri Simberg at the University of Colorado developed a nanogel specifically designed to treat Urinary Tract Infections (UTIs). The nanogel allows a localized and sustainable delivery of drugs within the urothelium. The nanogel is formed as a polymeric 3-dimensional network which is biodegradable and naturally excreted by the...

Published: 11/30/2023 | Inventor(s): Devatha Nair, Dmitri Simberg, Manju Saraswathy

Disease Areas Nephrology, Oncology, Regenerative Medicine

Category(s): Therapeutics