Amniocyte-derived Patch for Repair of Congenital Heart Defects


Challenge with Current Treatment for CHD
Congenital heart defects (CHD) are the most common type of birth defect and are considered a leading cause of birth defect-associated infant illness and death. About 40,000 babies are affected each year in the US (source: CDC). When treating patients with CHD, surgical repairs often require patches. Currently, polymers are the most common patch materials used in CHD repairs. However, these materials do not grow with the patient and may require further surgeries to replace the patch. Additionally, they have mismatched mechanical properties and a lack of contractility which can contribute to complications (heart failure, arrhythmia, and aneurysm). An ideal patch would be made of materials that are biocompatible, biodegradable and contain cardiac cells with contractility and conductivity similar to native cardiac tissue.

Poly Hydrogel Cardiac Patch
A University of Colorado research group led by Dr. Jeffrey Jacot has developed a new cardiac patch to treat CHDs. The multilayer patch has biodegradable engineered scaffolds and promotes tissue remodeling. Compared to current patches that are biologically inert, the present patch has a polyurethane core surrounded by a prevascularized structure that can attach to the host. Endothelial cells and mesenchymal stem cells derived from the amniotic fluid surrounding a fetus diagnosed with CHD are used to create the patch. In vitro and in vivo studies in rats have been completed and demonstrate that the patch is capable of full thickness defect repair and regeneration (Figure 1).


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Medical Devices
For Information, Contact:
Doreen Molk
University of Colorado
Jeffrey Jacot
Disease Areas:
Regenerative Medicine
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