Search Results - cardiology

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Neprilysin for the Treatment of Pulmonary Hypertension

Chronic pulmonary hypertension (cPH) is a major clinical problem, complicating most lung and heart disorders including chronic obstructive pulmonary disease (COPD). PH occurs when the pressure in the arteries of the lung is elevated, increasing resistance for the right side of the heart. This added burden causes shortness of breath, fluid retention...

Published: 12/1/2023 | Inventor(s): Edward Dempsey

Disease Areas Cardiology, Pulmonology

Category(s): Therapeutics

Treatment For Filamin C-Related Cardiomyopathies

Filamin C (FLNC) mutations have been identified as a genetic cause of dilated cardiomyopathy (DCM) with an arrhythmogenic phenotype and an increased risk for sudden cardiac death due to ventricular arrhythmias. Many of these patients also develop heart failure, requiring heart transplant. Unfortunately, there are currently no specific treatments...

Published: 5/10/2023 | Inventor(s): Suet Nee Chen, Luisa Mestroni, Joseph Wu, Matthew R.G. Taylor, Ying Wooi Wan, Chi Keung Lam

Disease Areas Cardiology, Regenerative Medicine

Category(s): Therapeutics

Integrating current rapid prototyping technology with advanced medical imaging

A research team led by John Carroll and James Chen with computer graphics input from Adam Hansgen developed a process to transform routinely obtained cardiac tomographic angiography (CTA), magnetic resonance angiography (MRA), and 3-D transesophageal ultrasound (TEE) images into a prototyping-ready format, so high-quality hollow models can be produced...

Published: 5/24/2023 | Inventor(s): John Carroll, Adam Hansgen, James Chen, Michael Kim

Disease Areas Cardiology

Category(s): Software

Nebivolol Treatment in Pediatric Heart Failure Patients

In contrast to adult heart failure, the pathophysiology of the development of myocardial dysfunction and heart failure in children is poorly understood. For example, traditional β-blocking agents have a clear benefit in the treatment of heart failure in adults but for pediatric patients, there is no demonstrated clinical benefit. To address this...

Published: 5/25/2023 | Inventor(s): Brian Stauffer, Carmen Sucharov, Shelley Miyamoto

Disease Areas Cardiology

Category(s): Therapeutics

NanoCardioLab: Exploring the Heart at the Micro-and Nanoscale

The inventors’ team, led by Dr. Luisa Mestroni of CU, has discovered that changes observed in neurons when exposed to carbon nanotubes (CNTs) could be reproduced in cardiac myocytes. Their work has shown increased viability and proliferation of cardiac myocytes (neonatal rat ventricular myocytes, NRVM) when interacting with CNTs, as well as changes...

Published: 5/24/2023 | Inventor(s): Luisa Mestroni, Laura Ballerini, Carlin Long, John Caldwell, Valentia Martinelli, Giada Cellot, Francesca Toma, Lorenza Zentilin, Maurizio Prato

Disease Areas Cardiology, Regenerative Medicine

Category(s): Therapeutics

Amniocyte-derived Patch for Repair of Congenital Heart Defects

Challenge with Current Treatment for CHD Congenital heart defects (CHD) are the most common type of birth defect and are considered a leading cause of birth defect-associated infant illness and death. About 40,000 babies are affected each year in the US (source: CDC). When treating patients with CHD, surgical repairs often require patches. Currently,...

Published: 10/5/2023 | Inventor(s): Jeffrey Jacot

Disease Areas Cardiology, Regenerative Medicine

Category(s): Medical Devices

Novel Method for Applying Vasoactive Substances

Dr. David Irwin of The University of Colorado and Dr Thies Schroeder look to overcome barriers to drug delivery in patients with pulmonary arterial hypertension with the development of their novel method for applying an endothelin blocking compound (Ambrisentan) in a reverse nanoshell emulsifier to the lungs via a nebulized mist. Oral and injectable...

Published: 5/30/2023 | Inventor(s): David Irwin, Thies Schroeder, Mark Borden, David Pak, Justin Hopkins

Disease Areas Cardiology

Category(s): Therapeutics

Carbon Nanotube-Functionalized Reverse Thermal Gel for Cardiac Tissue Engineering

Approximately 422.7 million heart diseases cases are diagnosed annually across the globe. The dysfunction and death of specialized muscle cells, cardiomyocytes, cause many of these heart failures to occur. The adult heart has scarce capability to regenerate these cells after injury and access to heart transplants is limited. Regenerative medicine has...

Published: 8/29/2022 | Inventor(s): Brisa Pena Castellanos, Daewon Park, Luisa Mestroni, Susanna Bosi

Disease Areas Cardiology

Category(s): Therapeutics