Six1 Monoclonal Antibody as a Diagnostic/Prognostic Reagent


The research group led by Dr. Heide Ford generated a monoclonal antibody to detect human SIX1, which is a transcription factor that contributes to cancer proliferation, survival, epithelial to mesenchymal transition, and lymphangiogenesis. The mouse IgG 2A antibody was created using recombinant SIX1 protein from amino acids 1-259. Importantly, the antibody does not cross react with other SIX family proteins and has been tested in western blotting and ELISA assays.


Behbakht K, Qamar L, et al. Six1 Overexpression in Ovarian Carcinoma Causes Resistance to TRAIL-Mediated Apoptosis and is Associated with Poor Survival. Cancer Research. 2007; 67(7):3036-42.


For Information, Contact:
Aaron Troemner
University of Colorado
Heide Ford
Disease Areas:
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