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Monoclonal Antibodies Specifically Targeting Six1

CU scientists have developed monoclonal antibodies targeting the C-terminus of Six1, which is a transcription factor important for development and formation of the muscle, kidney, inner ear, and other organs. Importantly, the antibody is specific to Six1 and is not cross-reactive with other Six family members. The antibody was generated by immunizing...

Published: 5/22/2023 | Inventor(s): Heide Ford, Aaron Patrick, Joshua (Deceased) Cabrera

Disease Areas Oncology

Category(s): Research Tools

Six1 Monoclonal Antibody as a Diagnostic/Prognostic Reagent

The research group led by Dr. Heide Ford generated a monoclonal antibody to detect human SIX1, which is a transcription factor that contributes to cancer proliferation, survival, epithelial to mesenchymal transition, and lymphangiogenesis. The mouse IgG 2A antibody was created using recombinant SIX1 protein from amino acids 1-259. Importantly, the antibody...

Published: 5/9/2023 | Inventor(s): Heide Ford

Disease Areas Oncology

Category(s): Diagnostics