A research team led by Dr. George Eisenbarth and Dr. Liping Yu has developed a novel method for the diagnosis and prediction of Type 1A diabetes in prediabetic patients. By exchanging the radioactive insulin with biotinylated and sulfo-tagged proinsulin, they were able to detect insulin autoantibodies with a plate based non-radioactive assay. This new method of plate capture for highly reproducible, non-radioactive testing for insulin autoantibodies can lead to the development of multiple assay formats to improve the prediction of Type 1A diabetes.