Search Results - george+eisenbarth+(deceased)

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Novel Insulin B Chain Peptide to Prevent and Treat Type I Diabetes
Researchers at the University of Colorado have developed a mimotope of insulin B chain amino acids 9-23 (B:9-23) which shows a 100-fold better binding to the HLA-DQ8 molecule and allows for binding in a register that activates CD4 T cells in the nonobese mouse model of spontaneous autoimmune diabetes and human peripheral blood. This allows for the ability...
Published: 11/29/2023   |   Inventor(s): Aaron Michels, George Eisenbarth (Deceased), John Kappler, Peter Gottlieb
Disease Areas Endocrine/Metabolism
Category(s): Therapeutics
Assay for Diagnosis of Type 1A Diabetes and Other Autoimmune Diseases
A research team led by Dr. George Eisenbarth and Dr. Liping Yu has developed a novel method for the diagnosis and prediction of Type 1A diabetes in prediabetic patients. By exchanging the radioactive insulin with biotinylated and sulfo-tagged proinsulin, they were able to detect insulin autoantibodies with a plate based non-radioactive assay. This new...
Published: 11/29/2023   |   Inventor(s): Liping Yu, George Eisenbarth (Deceased)
Disease Areas Immunology
Category(s): Diagnostics
Vaccine for Prevention and Treatment of Autoimmune Diseases
A research team led by Dr. George Eisenbarth has identified and tested a novel antigen-specific strategy for the prevention or treatment of autoimmune diseases. In this new approach, a compound (consisting of a natural immune-system molecule tethered to an autoantigenic peptide that is implicated in the development of a particular autoimmune disease)...
Published: 11/29/2023   |   Inventor(s): Li Zhang, John Kappler, Brian Stadinski, George Eisenbarth (Deceased)
Disease Areas Immunology
Category(s): Therapeutics
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