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Novel Insulin B Chain Peptide to Prevent and Treat Type I Diabetes

Researchers at the University of Colorado have developed a mimotope of insulin B chain amino acids 9-23 (B:9-23) which shows a 100-fold better binding to the HLA-DQ8 molecule and allows for binding in a register that activates CD4 T cells in the nonobese mouse model of spontaneous autoimmune diabetes and human peripheral blood. This allows for the ability...

Published: 11/29/2023 | Inventor(s): Aaron Michels, George Eisenbarth (Deceased), John Kappler, Peter Gottlieb

Disease Areas Endocrine/Metabolism

Category(s): Therapeutics