Search Results - aaron+michels

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Novel Multiplex Assays to Diagnose or Evaluate Diseases or Disorders in Mammals

A research group led by Dr. Liping Yu have developed multiplex assays which can be used for high throughput, simultaneous screening of T1D and its comorbidities using autoantibodies. These assays can measure up to ten autoantibodies using separate linkers for each labeled antigen and electrochemiluminescence detection. They require a small volume and...

Published: 11/29/2023 | Inventor(s): Liping Yu, Marian Rewers, Aaron Michels

Disease Areas Immunology

Category(s): Diagnostics

Novel Insulin B Chain Peptide to Prevent and Treat Type I Diabetes

Researchers at the University of Colorado have developed a mimotope of insulin B chain amino acids 9-23 (B:9-23) which shows a 100-fold better binding to the HLA-DQ8 molecule and allows for binding in a register that activates CD4 T cells in the nonobese mouse model of spontaneous autoimmune diabetes and human peripheral blood. This allows for the ability...

Published: 11/29/2023 | Inventor(s): Aaron Michels, George Eisenbarth (Deceased), John Kappler, Peter Gottlieb

Disease Areas Endocrine/Metabolism

Category(s): Therapeutics