Search Results - john+kappler

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Novel Insulin B Chain Peptide to Prevent and Treat Type I Diabetes

Researchers at the University of Colorado have developed a mimotope of insulin B chain amino acids 9-23 (B:9-23) which shows a 100-fold better binding to the HLA-DQ8 molecule and allows for binding in a register that activates CD4 T cells in the nonobese mouse model of spontaneous autoimmune diabetes and human peripheral blood. This allows for the ability...

Published: 11/29/2023 | Inventor(s): Aaron Michels, George Eisenbarth (Deceased), John Kappler, Peter Gottlieb

Disease Areas Endocrine/Metabolism

Category(s): Therapeutics

Mouse M12.C3 B cell lines that express insulin residues linked to the mouse MHC class II molecule I-AG7

A CU scientist developed two mouse cell lines that expresses variants of the insulin B-chain residues linked to the mouse MHC class II molecules of beta and alpha I-AG7. These cell lines are derivatives of the mouse M12.C3 B cell line, which was originally derived from Balb/c mice that are negative for MHC class II molecules. The first cell line, called...

Published: 5/22/2023 | Inventor(s): Tomasz Sosinowski, John Kappler

Disease Areas Immunology, Oncology

Category(s): Research Tools

Vaccine for Prevention and Treatment of Autoimmune Diseases

A research team led by Dr. George Eisenbarth has identified and tested a novel antigen-specific strategy for the prevention or treatment of autoimmune diseases. In this new approach, a compound (consisting of a natural immune-system molecule tethered to an autoantigenic peptide that is implicated in the development of a particular autoimmune disease)...

Published: 11/29/2023 | Inventor(s): Li Zhang, John Kappler, Brian Stadinski, George Eisenbarth (Deceased)

Disease Areas Immunology

Category(s): Therapeutics