Search Results - george+eisenbarth+(deceased)

3 Results

Sort By:

Novel Insulin B Chain Peptide to Prevent and Treat Type I Diabetes

Researchers at the University of Colorado have developed a mimotope of insulin B chain amino acids 9-23 (B:9-23) which shows a 100-fold better binding to the HLA-DQ8 molecule and allows for binding in a register that activates CD4 T cells in the nonobese mouse model of spontaneous autoimmune diabetes and human peripheral blood. This allows for the ability...

Published: 11/29/2023 | Inventor(s): Aaron Michels, George Eisenbarth (Deceased), John Kappler, Peter Gottlieb

Disease Areas Endocrine/Metabolism

Category(s): Therapeutics

Assay for Diagnosis of Type 1A Diabetes and Other Autoimmune Diseases

A research team led by Dr. George Eisenbarth and Dr. Liping Yu has developed a novel method for the diagnosis and prediction of Type 1A diabetes in prediabetic patients. By exchanging the radioactive insulin with biotinylated and sulfo-tagged proinsulin, they were able to detect insulin autoantibodies with a plate based non-radioactive assay. This new...

Published: 11/29/2023 | Inventor(s): Liping Yu, George Eisenbarth (Deceased)

Disease Areas Immunology

Category(s): Diagnostics

Vaccine for Prevention and Treatment of Autoimmune Diseases

A research team led by Dr. George Eisenbarth has identified and tested a novel antigen-specific strategy for the prevention or treatment of autoimmune diseases. In this new approach, a compound (consisting of a natural immune-system molecule tethered to an autoantigenic peptide that is implicated in the development of a particular autoimmune disease)...

Published: 11/29/2023 | Inventor(s): Li Zhang, John Kappler, Brian Stadinski, George Eisenbarth (Deceased)

Disease Areas Immunology

Category(s): Therapeutics