Search Results - immunology

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In vivo mouse model for testing immunotherapeutic drugs for autoimmune type 1 diabetes

Researchers developed an in vivo mouse model for testing immunotherapeutic drugs for autoimmune type-1 diabetes.

Published: 5/9/2023 | Inventor(s): Kathryn Haskins

Disease Areas Immunology

Category(s): Research Tools

Novel Multiplex Assays to Diagnose or Evaluate Diseases or Disorders in Mammals

A research group led by Dr. Liping Yu have developed multiplex assays which can be used for high throughput, simultaneous screening of T1D and its comorbidities using autoantibodies. These assays can measure up to ten autoantibodies using separate linkers for each labeled antigen and electrochemiluminescence detection. They require a small volume and...

Published: 11/29/2023 | Inventor(s): Liping Yu, Marian Rewers, Aaron Michels

Disease Areas Immunology

Category(s): Diagnostics

Innate Lymphoid Cell (ILC) Therapy for GvHD

High refractory and mortality of GvHD Hematopoietic stem cell transplantation (HSCT) is curative for a variety of malignant and non-malignant disorders with no other therapeutic options. Graft versus host disease (GvHD) accounts for morbidity and mortality after HSCT. GVHD occurs in 30 to 60% of HSCT cases and carries approximately a 50% mortality rate....

Published: 10/23/2023 | Inventor(s): Michael Verneris, Dejene Tufa

Disease Areas Immunology, Oncology

Category(s): Therapeutics

Lung Cancer Cell Lines with Specific Oncotic Drivers

CU researchers, led by Dr. Stephen Malkoski, developed 6 novel murine lung cancer cell lines with defined genetic mutations that are capable of transplantable tumor formation in immunocompetent hosts. The cell lines include various combinations of tumor suppressor and oncogene genetic variants. Mutant cell lines genotypes include: 1) KrasG12D.Smad4+/− 2)...

Published: 5/22/2023 | Inventor(s): Stephen Malkoski

Disease Areas Immunology, Oncology, Pulmonology

Category(s): Research Tools

Mouse M12.C3 B cell lines that express insulin residues linked to the mouse MHC class II molecule I-AG7

A CU scientist developed two mouse cell lines that expresses variants of the insulin B-chain residues linked to the mouse MHC class II molecules of beta and alpha I-AG7. These cell lines are derivatives of the mouse M12.C3 B cell line, which was originally derived from Balb/c mice that are negative for MHC class II molecules. The first cell line, called...

Published: 5/22/2023 | Inventor(s): Tomasz Sosinowski, John Kappler

Disease Areas Immunology, Oncology

Category(s): Research Tools

Antigen Presenting Cell Line Expressing HLA-DQ8

CU researchers developed a human myelogenic leukemia cell line that expresses a human leukocyte antigen HLA-DQ8 (DQA1*0301 and DQB1*0302). The cell line is a derivative of K562, which was obtained from the bone marrow of a 53-year-old female with chronic myelogenous leukemia. Here, the K562 cell line was engineered using a replication-incompetent retrovirus...

Published: 5/22/2023 | Inventor(s): Maki Nakayama

Disease Areas Immunology

Category(s): Research Tools

Induction of Regulatory B Cells for the Treatment of Immune-Mediated Diseases

A research group led by Dr Susan Childress have developed a novel treatment for a variety of immune-mediated diseases. The complement receptors CR1 and CR2 are known to be involved in the induction of B cells under inflammatory conditions that occur in immune-mediated diseases. Through administering an IncRNA sequence that regulates CR1 expression,...

Published: 5/26/2023 | Inventor(s): Susan Boackle

Disease Areas Immunology

Category(s): Therapeutics

A Novel Non-Immunogenic Mouse Monoclonal Antibody that Recognizes Mouse CR2 and Inhibits its Function in Chronic Disease Models

CU investigators have generated a novel antibody that recognizes Compliment Receptor 2 (CR2). This antibody was raised in CR2 deficient mice and is non-immunogenic when administered in vivo. Importantly, the antibody blocks the function of mouse CR2 and can be used to study how CR2 receptor blockage modifies disease activity in proof-of-concept mouse...

Published: 5/22/2023 | Inventor(s): V. Michael Holers, Liudmila Kulik

Disease Areas Immunology

Category(s): Research Tools

Antibody to Detect Mouse LINE-1 ORF-1 Protein

CU investigators have generated a polyclonal antibody to detect mouse ORF1 protein, which is required for retrotransposition of the LINE-1 retrotransposon. The antibody was generated by immunizing rabbits with recombinant mouse ORF1 protein. Testing shows that the antibody is highly specific and capable of detecting 1 ng of protein in a western blot....

Published: 5/9/2023 | Inventor(s): Sandra Martin

Disease Areas Immunology

Category(s): Research Tools

Assay for Diagnosis of Type 1A Diabetes and Other Autoimmune Diseases

A research team led by Dr. George Eisenbarth and Dr. Liping Yu has developed a novel method for the diagnosis and prediction of Type 1A diabetes in prediabetic patients. By exchanging the radioactive insulin with biotinylated and sulfo-tagged proinsulin, they were able to detect insulin autoantibodies with a plate based non-radioactive assay. This new...

Published: 11/29/2023 | Inventor(s): Liping Yu, George Eisenbarth (Deceased)

Disease Areas Immunology

Category(s): Diagnostics

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