Search Results - v.+michael+holers

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A Novel Non-Immunogenic Mouse Monoclonal Antibody that Recognizes Mouse CR2 and Inhibits its Function in Chronic Disease Models

CU investigators have generated a novel antibody that recognizes Compliment Receptor 2 (CR2). This antibody was raised in CR2 deficient mice and is non-immunogenic when administered in vivo. Importantly, the antibody blocks the function of mouse CR2 and can be used to study how CR2 receptor blockage modifies disease activity in proof-of-concept mouse...

Published: 5/22/2023 | Inventor(s): V. Michael Holers, Liudmila Kulik

Disease Areas Immunology

Category(s): Research Tools

Composition and description of novel anti-C3d monoclonal antibodies used for non-invasive detection of complement activation fragments in vivo

Systemic lupus erythematosus (SLE) is an autoimmune disease which can affect different organs throughout the body and is battled by nearly 4 million Americans in the United States. Up to 50% of patients with SLE develop renal abnormalities during the disease’s progression. Not only are biopsies invasive and carry their own complications, but the...

Published: 12/1/2023 | Inventor(s): V. Michael Holers, Joshua Thurman, Liudmila Kulik

Disease Areas Immunology

Category(s): Diagnostics

Treatment of Rheumatoid Arthritis with a Novel siRNA-IgG Conjugate

Though the therapeutics currently available for the treatment of rheumatoid arthritis (RA) have dramatically improved the lives of patients, a large subset of patients show little to no response to treatment. Dr Band and colleagues have identified novel targets in the complement system for the treatment of rheumatoid arthritis (RA). Previous work from...

Published: 11/30/2023 | Inventor(s): Nirmal Banda, V. Michael Holers

Disease Areas Immunology

Category(s): Therapeutics