Search Results - therapeutics

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Neprilysin for the Treatment of Pulmonary Hypertension

Chronic pulmonary hypertension (cPH) is a major clinical problem, complicating most lung and heart disorders including chronic obstructive pulmonary disease (COPD). PH occurs when the pressure in the arteries of the lung is elevated, increasing resistance for the right side of the heart. This added burden causes shortness of breath, fluid retention...

Published: 12/1/2023 | Inventor(s): Edward Dempsey

Disease Areas Cardiology, Pulmonology

Category(s): Therapeutics

Logic Gated CAR-T Therapy for Pediatric Brain Tumors

Diffuse Intrinsic Pontine Glioma DIPG (Diffuse Intrinsic Pontine Glioma) is a highly aggressive brain tumor in children, primarily located in the pons region. It's inoperable due to the tumor’s location, and chemotherapy agents have the inability to cross the blood-brain barrier. Radiation offers only temporary relief, and the 5-year survival...

Published: 12/1/2023 | Inventor(s): Sujatha Venkataraman, Mark Kohler

Disease Areas Pediatrics

Category(s): Therapeutics

CAR-T Targets Novel CD99 in Pediatric Brain Tumor

Challenges in DIPG Treatment The field of Diffuse Intrinsic Pontine Glioma (DIPG) tumors faces a formidable challenge in the realm of pediatric oncology. These tumors, located in the brainstem, are inoperable due to their diffuse and infiltrative nature, rendering surgical removal impossible. Furthermore, the blood-brain barrier poses a significant...

Published: 12/1/2023 | Inventor(s): Sujatha Venkataraman, Rajeev Vibhakar

Disease Areas Pediatrics

Category(s): Therapeutics

Homing of Chimeric Antigen Receptor Expressing T cells to Solid Tumors

One major challenge in targeting CAR T cells to patients with solid tumors is the limited homing of CAR T cells to solid tumors. The University of Colorado research group led by Dr Michael Verneris has developed a CAR construct to target CAR-T cells to IL-8 (CXCL8) producing target tumors. This chemokine is commonly expressed by tumors (brain, lung,...

Published: 10/27/2023 | Inventor(s): Michael Verneris, Jessica Lake

Disease Areas Oncology

Category(s): Therapeutics

Enhancement of Islet β-cell based therapies for T1D

Cell Therapy for T1D While insulin replacement therapy has long been the standard of care for individuals with Type 1 Diabetes (T1D), it represents a lifelong treatment burden, replete with associated complications, such as hypoglycemia from repeated insulin injections, neuropathies, as well as kidney failure, and ongoing financial costs. In contrast,...

Published: 10/11/2023 | Inventor(s): Holger Russ, Fiona Docherty

Disease Areas Regenerative Medicine

Category(s): Therapeutics

High Efficiency Generation of Integration-free iPSCs for the Clinic

iPSC Reprogramming Challenges Induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cell generated directly from adult cells that can propagate indefinitely to give rise to every other cell type in the body. iPSCs are a valuable tool to study human development and disease. They are also useful for drug discovery and the development of...

Published: 10/6/2023 | Inventor(s): Igor Kogut, Dennis Roop, Ganna Bilousova

Disease Areas Dermatology, Regenerative Medicine

Category(s): Therapeutics

Genetically Engineered Treg Cell Therapy for Immune Disorders

Adoptive Cell Therapies for Chronic Inflammatory and Autoimmune Disorders Chronic inflammatory and autoimmune disorders affect over 3% of the US population with no treatment options available that sustainably reverses symptoms or cures patients. Adoptive Treg cell therapies are promising treatment options due to their ability to persistently induce...

Published: 10/23/2023 | Inventor(s): Mayumi Fujita, Douglas Osborne, Maki Nakayama

Disease Areas Regenerative Medicine

Category(s): Therapeutics

CD8 Targeting CAR-T Cells for Autoimmune Disorders

Necessity of CAR-T Targeting Autoimmunity There is a need for more antigen targets for CAR-based therapies treating autoimmune disorders, solid organ transplant rejection, and T-cell leukemia. Pathogenic CD8 T-cells are one of the drivers for the listed indications and presents a promising target for CAR-based therapies. CD8 Targeting CAR-T Cell Therapy Dr....

Published: 10/23/2023 | Inventor(s): Terry Fry

Disease Areas Regenerative Medicine

Category(s): Therapeutics

Novel Costimulatory Platform for CAR-Based Adoptive Cell Therapies

Ineffective targeting of current CAR T Chimeric antigen receptor (CAR) T cell therapy is a powerful treatment tool for multiple types of malignancies. There are six FDA approved CAR T therapies that have demonstrated efficacy in patients who are refractory to standard chemotherapy, with many patients entering remission after treatment. However, most...

Published: 10/23/2023 | Inventor(s): Mark Kohler, Terry Fry, Catherine Danis, Lillie Leach

Disease Areas Regenerative Medicine

Category(s): Therapeutics

RNA Cocktail to Restore Function in Aged Cells

Aged Cells or Tissues used for Autologous Therapies have Poor Efficacy Autologous cells used for tissue transplant therapies or adoptive cell therapies become poorly functional because of aging caused by either (1) patient age (elderly patient) or (2) induced aging via ex-vivo expansion protocols. Restoring function in aged cells is critical to improve...

Published: 9/27/2023 | Inventor(s): Igor Kogut, Ganna Bilousova, Patrick McGrath, Nicole Diette

Disease Areas Regenerative Medicine

Category(s): Therapeutics

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