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Logic Gated CAR-T Therapy for Pediatric Brain Tumors

Diffuse Intrinsic Pontine Glioma DIPG (Diffuse Intrinsic Pontine Glioma) is a highly aggressive brain tumor in children, primarily located in the pons region. It's inoperable due to the tumor’s location, and chemotherapy agents have the inability to cross the blood-brain barrier. Radiation offers only temporary relief, and the 5-year survival...

Published: 12/1/2023 | Inventor(s): Sujatha Venkataraman, Mark Kohler

Disease Areas Pediatrics

Category(s): Therapeutics

Novel Costimulatory Platform for CAR-Based Adoptive Cell Therapies

Ineffective targeting of current CAR T Chimeric antigen receptor (CAR) T cell therapy is a powerful treatment tool for multiple types of malignancies. There are six FDA approved CAR T therapies that have demonstrated efficacy in patients who are refractory to standard chemotherapy, with many patients entering remission after treatment. However, most...

Published: 10/23/2023 | Inventor(s): Mark Kohler, Terry Fry, Catherine Danis, Lillie Leach

Disease Areas Regenerative Medicine

Category(s): Therapeutics

Novel Costimulatory Platform for CAR-Based Adoptive Cell Therapies

Published: 10/23/2023 | Inventor(s): Mark Kohler, Catherine Danis, Terry Fry, Lillie Leach

Disease Areas Regenerative Medicine

Category(s): Therapeutics