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Logic Gated CAR-T Therapy for Pediatric Brain Tumors

Diffuse Intrinsic Pontine Glioma DIPG (Diffuse Intrinsic Pontine Glioma) is a highly aggressive brain tumor in children, primarily located in the pons region. It's inoperable due to the tumor’s location, and chemotherapy agents have the inability to cross the blood-brain barrier. Radiation offers only temporary relief, and the 5-year survival...

Published: 12/1/2023 | Inventor(s): Sujatha Venkataraman, Mark Kohler

Disease Areas Pediatrics

Category(s): Therapeutics

CAR-T Targets Novel CD99 in Pediatric Brain Tumor

Challenges in DIPG Treatment The field of Diffuse Intrinsic Pontine Glioma (DIPG) tumors faces a formidable challenge in the realm of pediatric oncology. These tumors, located in the brainstem, are inoperable due to their diffuse and infiltrative nature, rendering surgical removal impossible. Furthermore, the blood-brain barrier poses a significant...

Published: 12/1/2023 | Inventor(s): Sujatha Venkataraman, Rajeev Vibhakar

Disease Areas Pediatrics

Category(s): Therapeutics