Search Results - regenerative+medicine

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Nanosilk Fibers for Pressure Ulcer Prevention

Pressure-induced skin injuries are areas of damage to the skin or underlying tissue as a result of pressure or shear. Pressure-induced skin and soft tissue injuries are considered never events by CMS. There has been an unmet need for devices for the prevention of pressure ulcers. Recent developments in polymer-based nanofabrication shows promise...

Published: 12/1/2023 | Inventor(s): Kenneth Liechty, Sudipta Seal, Swetha Barkam

Disease Areas Dermatology, Regenerative Medicine

Category(s): Medical Devices

Automated iPSC to Cardiac Muscle Differentiation

Cardiomyocytes Cardiomyopathies disrupt heart muscle function, causing irreversible, enduring issues. Current treatment mainly alleviates symptoms, often necessitating heart transplants. The specialized muscle cells of the heart, known as cardiomyocytes (CM), have limited capacity for replication and are in a terminal state of differentiation. This...

Published: 10/12/2023 | Inventor(s): Jeffrey Jacot, Christopher Tsao, Ennio Tasciotti

Disease Areas Dermatology, Regenerative Medicine

Category(s): Medical Devices

Enhancement of Islet β-cell based therapies for T1D

Cell Therapy for T1D While insulin replacement therapy has long been the standard of care for individuals with Type 1 Diabetes (T1D), it represents a lifelong treatment burden, replete with associated complications, such as hypoglycemia from repeated insulin injections, neuropathies, as well as kidney failure, and ongoing financial costs. In contrast,...

Published: 10/11/2023 | Inventor(s): Holger Russ, Fiona Docherty

Disease Areas Regenerative Medicine

Category(s): Therapeutics

High Efficiency Generation of Integration-free iPSCs for the Clinic

iPSC Reprogramming Challenges Induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cell generated directly from adult cells that can propagate indefinitely to give rise to every other cell type in the body. iPSCs are a valuable tool to study human development and disease. They are also useful for drug discovery and the development of...

Published: 10/6/2023 | Inventor(s): Igor Kogut, Dennis Roop, Ganna Bilousova

Disease Areas Dermatology, Regenerative Medicine

Category(s): Therapeutics

Genetically Engineered Treg Cell Therapy for Immune Disorders

Adoptive Cell Therapies for Chronic Inflammatory and Autoimmune Disorders Chronic inflammatory and autoimmune disorders affect over 3% of the US population with no treatment options available that sustainably reverses symptoms or cures patients. Adoptive Treg cell therapies are promising treatment options due to their ability to persistently induce...

Published: 10/23/2023 | Inventor(s): Mayumi Fujita, Douglas Osborne, Maki Nakayama

Disease Areas Regenerative Medicine

Category(s): Therapeutics

CD8 Targeting CAR-T Cells for Autoimmune Disorders

Necessity of CAR-T Targeting Autoimmunity There is a need for more antigen targets for CAR-based therapies treating autoimmune disorders, solid organ transplant rejection, and T-cell leukemia. Pathogenic CD8 T-cells are one of the drivers for the listed indications and presents a promising target for CAR-based therapies. CD8 Targeting CAR-T Cell Therapy Dr....

Published: 10/23/2023 | Inventor(s): Terry Fry

Disease Areas Regenerative Medicine

Category(s): Therapeutics

Novel Costimulatory Platform for CAR-Based Adoptive Cell Therapies

Ineffective targeting of current CAR T Chimeric antigen receptor (CAR) T cell therapy is a powerful treatment tool for multiple types of malignancies. There are six FDA approved CAR T therapies that have demonstrated efficacy in patients who are refractory to standard chemotherapy, with many patients entering remission after treatment. However, most...

Published: 10/23/2023 | Inventor(s): Mark Kohler, Terry Fry, Catherine Danis, Lillie Leach

Disease Areas Regenerative Medicine

Category(s): Therapeutics

RNA Cocktail to Restore Function in Aged Cells

Aged Cells or Tissues used for Autologous Therapies have Poor Efficacy Autologous cells used for tissue transplant therapies or adoptive cell therapies become poorly functional because of aging caused by either (1) patient age (elderly patient) or (2) induced aging via ex-vivo expansion protocols. Restoring function in aged cells is critical to improve...

Published: 9/27/2023 | Inventor(s): Igor Kogut, Ganna Bilousova, Patrick McGrath, Nicole Diette

Disease Areas Regenerative Medicine

Category(s): Therapeutics

High Efficiency Generation of Integration-free iPSCs for the Clinic

Published: 10/6/2023 | Inventor(s): Ganna Bilousova, Igor Kogut, Dennis Roop, Patrick McGrath

Disease Areas Regenerative Medicine

Category(s): Therapeutics

Generation of Human Motor Neurons

Lack in development of human motor neurons Human motor neuron diseases are irreversible and devastating diseases for which there are no curative treatments. Amyotrophic lateral sclerosis (ALS), spinal muscular atrophy, primary lateral sclerosis, and peripheral diabetic neuropathy are a few diseases that affect the motor neurons. Of these, ALS is the...

Published: 9/27/2023 | Inventor(s): Holger Russ, Lori Sussel, Laura Hudish

Disease Areas Regenerative Medicine

Category(s): Research Tools

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