Search Results - dermatology

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Nanosilk Fibers for Pressure Ulcer Prevention

Pressure-induced skin injuries are areas of damage to the skin or underlying tissue as a result of pressure or shear. Pressure-induced skin and soft tissue injuries are considered never events by CMS. There has been an unmet need for devices for the prevention of pressure ulcers. Recent developments in polymer-based nanofabrication shows promise...

Published: 12/1/2023 | Inventor(s): Kenneth Liechty, Sudipta Seal, Swetha Barkam

Disease Areas Dermatology, Regenerative Medicine

Category(s): Medical Devices

Automated iPSC to Cardiac Muscle Differentiation

Cardiomyocytes Cardiomyopathies disrupt heart muscle function, causing irreversible, enduring issues. Current treatment mainly alleviates symptoms, often necessitating heart transplants. The specialized muscle cells of the heart, known as cardiomyocytes (CM), have limited capacity for replication and are in a terminal state of differentiation. This...

Published: 10/12/2023 | Inventor(s): Jeffrey Jacot, Christopher Tsao, Ennio Tasciotti

Disease Areas Dermatology, Regenerative Medicine

Category(s): Medical Devices

High Efficiency Generation of Integration-free iPSCs for the Clinic

iPSC Reprogramming Challenges Induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cell generated directly from adult cells that can propagate indefinitely to give rise to every other cell type in the body. iPSCs are a valuable tool to study human development and disease. They are also useful for drug discovery and the development of...

Published: 10/6/2023 | Inventor(s): Igor Kogut, Dennis Roop, Ganna Bilousova

Disease Areas Dermatology, Regenerative Medicine

Category(s): Therapeutics

Immune targeting for the treatment of Cutaneous T-Cell Lymphoma

Cutaneous T-Cell Lymphoma (CTCL) has risen dramatically and consistently since 1973 with approximately 1,600 new cases of CTCL diagnosed each year in the US. Currently, there is no cure for CTCL and it is characterized by a chronic, relapsing course that requires repeat treatment regimens. The survival and response rate to CTCL therapeutics are only...

Published: 7/6/2023 | Inventor(s): Zhirui Wang, Christene Huang, David Mathes, Elizabeth Pomfret

Disease Areas Dermatology, Immunology, Oncology

Category(s): Therapeutics

MCL1 Inhibitor Combination Therapy for the Treatment of Melanoma

Melanoma causes the majority of skin cancer related deaths in the US despite only accounting for 1% of skin cancer cases. Immunotherapy has improved survival for melanoma patients, however 50% of these individuals will be refractory to first line treatment. Dr. Shellman and her team at the University of Colorado have identified a MCL1 inhibitor-immunotherapy...

Published: 5/22/2023 | Inventor(s): Yiqun Shellman, Richard Tobin, David Norris

Disease Areas Dermatology, Oncology

Category(s): Therapeutics