Search Results - pulmonology

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Neprilysin for the Treatment of Pulmonary Hypertension

Chronic pulmonary hypertension (cPH) is a major clinical problem, complicating most lung and heart disorders including chronic obstructive pulmonary disease (COPD). PH occurs when the pressure in the arteries of the lung is elevated, increasing resistance for the right side of the heart. This added burden causes shortness of breath, fluid retention...

Published: 12/1/2023 | Inventor(s): Edward Dempsey

Disease Areas Cardiology, Pulmonology

Category(s): Therapeutics

Lung Cancer Cell Lines with Specific Oncotic Drivers

CU researchers, led by Dr. Stephen Malkoski, developed 6 novel murine lung cancer cell lines with defined genetic mutations that are capable of transplantable tumor formation in immunocompetent hosts. The cell lines include various combinations of tumor suppressor and oncogene genetic variants. Mutant cell lines genotypes include: 1) KrasG12D.Smad4+/− 2)...

Published: 5/22/2023 | Inventor(s): Stephen Malkoski

Disease Areas Immunology, Oncology, Pulmonology

Category(s): Research Tools

Transgenic mice that overexpress Muc5b in the lungs

CU researchers have created a transgenic mouse model that overexpresses a major gel-forming mucin, Muc5b, in the lungs. To drive tissue-specific expression, the coding region of Muc5b is under control of the rat secretoglobin 1a1 (Scgb1a1) promoter. Evidence from human patient samples combined with this mouse model have been used demonstrate that excess...

Published: 5/22/2023 | Inventor(s): David Schwartz

Disease Areas Pulmonology

Category(s): Research Tools

Protective Role of MUC5B in Airflow Obstruction

In the lungs, the two major airway mucins secreted into airspaces are MUC5AC and MUC5B. In human asthma, both mucins are expressed at similar levels. In mice, Muc5ac is required for the development of asthma-like airflow obstruction. In this discovery, the Evans lab reports that Muc5b is protective in a mouse asthma model. This is the first time showing...

Published: 5/30/2023 | Inventor(s): Christopher Evans

Disease Areas Pulmonology

Category(s): Therapeutics

COPD Prognosis, Diagnosis and Therapy: A Personalized Medicine Approach

Chronic Obstructive Pulmonary Disease (COPD) is a progressive, life threatening disease that manifests with difficulty in breathing for which there is no cure. Dr. Raul Torres and Dr. John Hartney have identified a previously uncharacterized signaling pathway used by murine and human macrophages to promote pulmonary inflammation that relies on autocrine...

Published: 8/25/2023 | Inventor(s): Raul Torres, John Hartney, Roberta Pelanda

Disease Areas Pulmonology

Category(s): Therapeutics

Transgenic mouse model of pulmonary hypertension

The inventors have developed a system of transgenic mice in which the mutation found in human families, loss of the type II BMP receptor, is recreated in an inducible and tissue specific manner, to be used as an in vivo model with high molecular fidelity. The dominant negative transgene consists of a promoter, gene, and polyadenylation sequence. The...

Published: 5/22/2023 | Inventor(s): James West, David Rodman

Disease Areas Pulmonology

Category(s): Research Tools

Therapeutic Antioxidant Peptides

Pulmonary hypertension (PH) is a multifaceted disease characterized by high blood pressure in the lungs, a life-threatening complication with no current cure. An important pathophysiological mechanism in PH is oxidative stress which promote abnormal vascular responses. Superoxide dismutases are the major antioxidant defense systems against O2- by catalyzing...

Published: 7/5/2023 | Inventor(s): Leah Villegas, MyPhuong Le

Disease Areas Pulmonology

Category(s): Therapeutics