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Serum Immunoglobulin G1 (IgG1) and G3 (IgG3) subclasses as biomarkers for multiple sclerosis

Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS with demyelination and neuronal damage and is the most common cause of neurological disability in young adults. In 2021, roughly 784,000 Americans were living with MS. A characteristic feature of MS is the increased intrathecal synthesis of IgG, and the presence of oligoclonal...

Published: 6/7/2023 | Inventor(s): Xiaoli Yu, Michael Graner, Wenbo Zhou, Timothy Vollmer, Enrique Alvarez

Disease Areas

Category(s): Diagnostics

Using Milk Exosomes to Enhance Oral Drug Delivery

Problem: Many pharmaceuticals must be administered intravenously due to their poor oral bioavailability. In addition to issues associated with sterility and inconvenience, the cost of repeated infusion over a six-week course of therapy costs the healthcare system tens of billions of dollars per year and forces some patients to leave the comfort of their...

Published: 5/26/2023 | Inventor(s): Thomas Anchordoquy, Michael Graner, Jamie Betker, Brittany Angle

Disease Areas Oncology

Category(s): Therapeutics