Search Results - ram+nagaraj

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Monoclonal Antibody to ab-Crystallin Chaperone Protein ABCP

CU investigators have generated a monoclonal antibody that recognizes the protein ABCP, which is the core domain of molecular chaperone protein alpha,beta-crystallin. The antibody isotype is IgG2a1 and can be used to detect ABCP as well as a peptide region within ab-crystallin where ABCP binds. The research team has demonstrated that the antibody is...

Published: 5/22/2023 | Inventor(s): Ram Nagaraj, Rooban Nahomi

Disease Areas Ophthalmology

Category(s): Research Tools

A Novel Inhibitor for Advanced Glycation and Protein Crosslinking

Dr. Ram Nagaraj and a team of researchers have developed a novel molecule, Carboxitin that significantly reduces crosslinking and Advanced Glycation Endproducts (AGEs) formation in eye tissues to reduce lens stiffness. This compound may have the potential to treat diabetic eye complications, cataracts, presbyopia, and age-related macular degeneration....

Published: 5/22/2023 | Inventor(s): Ram Nagaraj, Mikhal Linetsky, Rooban Nahomi, Stefan Rakete

Disease Areas Ophthalmology

Category(s): Therapeutics

Gene Therapy for Retinal Ganglion Cell Protection in Glaucoma

Glaucoma is the leading cause of blindness worldwide. Recent advances in the treatment of glaucoma have improved intraocular pressure reduction and increased length of therapy release compared to traditional treatment options. However, poor patient treatment compliance and the resulting permanent vision loss due to retinal ganglion cell (RGC) death...

Published: 8/7/2023 | Inventor(s): Ram Nagaraj, Rooban Nahomi

Disease Areas Regenerative Medicine

Category(s): Therapeutics