Monoclonal Antibody to ab-Crystallin Chaperone Protein ABCP


CU investigators have generated a monoclonal antibody that recognizes the protein ABCP, which is the core domain of molecular chaperone protein alpha,beta-crystallin. The antibody isotype is IgG2a1 and can be used to detect ABCP as well as a peptide region within ab-crystallin where ABCP binds. The research team has demonstrated that the antibody is useful in western blots, ELISA assays, immunohistochemistry, and even inhibition of ab-crystallin protein function in animal models of disease. The antibody can be used in mouse and human tissues.


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Mary Tapolsky
University of Colorado
Ram Nagaraj
Rooban Nahomi
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