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Novel Compounds Targeting RNA Polymerase Binding Transcription Factor DksA for Treatment of Drug-Resistant Gram-Negative Infections

Scientists at the University of Colorado and National Jewish Health have identified novel compounds that specifically inhibit DksA activity in Gram-negative bacteria. Drugs against DksA have antibiotic activity against several Gram-negative pathogens. Moreover, the newly discovered drugs act against persistent populations of intracellular bacteria and...

Published: 5/26/2023 | Inventor(s): Michael Wempe, Andres Vazquez-Torres, Shaodong Dai

Disease Areas Infectious Disease

Category(s): Therapeutics