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PI3-k p110 delta inhibitors for treatment of autoimmunity

Variations in expression and/or function of a number of genes confer increased risk of development of autoimmunity. Among these variations is the expression negative regulators of the PI3K pathway, whose activity is critical in maintaining B cell anergy or unresponsiveness. Acute deletion of SHIP-1 or PTEN in autoreactive B cells leads to autoimmunity....

Published: 11/30/2023 | Inventor(s): John Cambier, Elizabeth Franks

Disease Areas Immunology

Category(s): Therapeutics